68Ga-NODAGA-Exendin-4 PET/CT Improves the Detection of Focal Congenital Hyperinsulinism

• DOI: 10.2967/jnumed.121.262327
• Publication Date: 2021-07-02T21:51:40Z
• Authors: Marti Boss; Christof Rottenbu...; Winfried Brenner; Oliver Blankenstein; Vikas Prasad; Sonal Prasad; Paolo de Coppi; Peter Kühnen; Mijke Buitinga; Pirjo Nuutila; Timo Otonkoski; Khalid Hussain; Maarten Brom; Annemarie Eek; Jamshed Bomanji; Pratik Shah; Martin Gotthardt
• Keywords: Congenital hyperinsulinism; PET-CT

Surgery with curative intent can be offered to congenital hyperinsulinism (CHI) patients, provided that the lesion is focal. Radiolabeled exendin-4 specifically binds glucagonlike peptide 1 receptor on pancreatic β-cells. In this study, we compared performance of 18F-DOPA PET/CT, current standard imaging method for CHI, and PET/CT new tracer 68Ga-NODAGA-exendin-4 in preoperative detection focal CHI. Methods: Nineteen CHI patients underwent both before surgery. The images were evaluated 3 settings: a clinical reading, masked expert joint reading. target (lesion)-to-nontarget (normal pancreas) ratio was determined using SUVmax Image quality rated by pediatric surgeons questionnaire. Results: Fourteen 19 having lesions On basis readings, sensitivity (100%; 95% CI, 77%-100%) higher than (71%; 42%-92%). Interobserver agreement between readings (Fleiss κ = 0.91 vs. 0.56). significantly (P 0.021) target-to-nontarget ratios (2.02 ± 0.65) did (1.40 0.40). 5-point scale, as superior PET/CT. Conclusion: For has better interobserver correlation Better contrast image make surgeons' intraoperative quest localization.