First-in-Human212Pb-PSMA–Targeted α-Therapy SPECT/CT Imaging in a Patient with Metastatic Castration-Resistant Prostate Cancer

• DOI: 10.2967/jnumed.123.267189
• Publication Date: 2024-02-29T19:40:15Z
• Authors: Matthew R. Griffiths; David A. Pattison; Melissa Latter; Kevin Kuan; Stephen Taylor; William Tieu; Thomas Kryza; Danielle Meyrick; Boon Quan Lee; Aaron Hansen; Stephen E. Rose; Simon G. Puttick
• Keywords: Spect imaging; Cancer Imaging; PET Imaging

There is significant interest in the development of 212Pb-PSMA–based targeted α-therapy for patients with metastatic castration-resistant prostate cancer. A previous phantom study has shown that 212Pb SPECT feasible by imaging 238.6 keV and 75 to 91 γ-emissions produced after β-