Multifunctionality of statins as antimicrobials

• DOI: 10.30574/wjbphs.2022.11.3.0114
• Publication Date: 2022-09-10T09:06:07Z
• Authors: Balbina J Plotkin; Alexis Borrelli; Matthew Erbst; Victoria Zheng; Monika I Konaklieva; Nicholas Schileru; Ira M Sigar
• Keywords: 0301 basic medicine; 0303 health sciences; 03 medical and health sciences; Fungi 1; Sar-CoV-2 2; Antimicrobial resistance 3; Lactone 4; Biofilm 5; Cholesterol 6; 3. Good health

The potential of statins as antimicrobials has been recognized for more than a decade; unfortunately, minimal progress in exploring this promise. This mini review highlights the structure of statins and their relevance as antimicrobial co-drug. The current information on the inhibition mechanism of statins on bacterial, fungal, viral, and biofilms is also described.