Normal-But-Low Serum Folate Levels and the Risks for Cognitive Impairment

• DOI: 10.30773/pi.2019.05.29
• Publication Date: 2019-07-26T00:42:58Z
• Authors: Soomin Jang; Ji Won Han; Jiyoon Shin; Tae Hui Kim; Kyung Phil Kwak; Kayoung Kim; Bong Jo Kim; Shin Gyeom Kim; Jeong Lan Kim; Tae Hyun Kim; Seok Woo Moon; Jae Young Park; Joon Hyuk Park; Seonjeong Byun; Seung Wan Suh; Jiyeong Seo; Yoonseop So; Seung-Ho Ryu; Jong Chul Youn; Kyoung Hwan Lee; Dong Young Lee; Dong Woo Lee; Seok Bum Lee; Jung Jae Lee; Ju Ri Lee; Hyeon Jeong; Hyun-Ghang Jeong; Jin Hyeong Jhoo; Kyuhee Han; Jong Woo Hong; Ki Woong Kim
• Keywords: Quartile; Rotterdam Study

This study aimed to examine the association between normal-but-low folate levels and cognitive function in elderly population using a prospective cohort study.We analyzed 3,910 participants whose serum were within normal reference range (1.5-16.9 ng/mL) at baseline evaluation population-based named "Korean Longitudinal Study on Cognitive Aging Dementia." The quartile categories disorders [mild impairment (MCI) or dementia] was examined binary logistic regression analysis adjusting for confounding variables. risks of incident MCI dementia associated with decline level during 4-year follow-up period multinomial analysis.The lowest group (≥1.5, ≤5.9 showed higher risk than did highest (odds ratio 1.314, p=0.012). Over 4 years follow-up, 2.364 times among subjects declined from 2nd-4th 1st those whom it not (p=0.031).Normal-but-low population, dementia. Maintaining concentration above 5.9 ng/mL may be beneficial status.