High-dose Meloxicam Provides Improved Analgesia in Female CD1 Mice: A Pharmacokinetic and Efficacy Study

• DOI: 10.30802/aalas-jaalas-22-000064
• Publication Date: 2023-01-04T20:08:57Z
• Authors: Jeffrey Kim; Brinley A Cannon; Layne E Freeman; Sarah Tan; Heather K Knych; Lon V Kendall
• Keywords: Meloxicam; Regimen; Subcutaneous injection

Meloxicam is a nonsteroidal anti-inflammatory analgesic drug that often used in mice. However, doses of 1 to 5 mg/kg given twice daily were recently reported provide inadequate analgesia. Some studies suggest up 20 may be necessary for adequate pain management. We investigated the analgesia provided by high-dose meloxicam female CD1 Pharmacokinetic analyses demonstrated subcutaneous injection 10 or produced therapeutic plasma concentrations at least 12 h. Ovariectomies via ventral laparotomy performed assess efficacy. Mice treated immediately before surgery with mg/kg, low-dose 2.5 saline, followed every h 36 At 3, 6, 12, 24, and 48 after surgery, mice assessed based on following behaviors: distance traveled, time mobile, grooming, rearing, hunched posture, orbital tightening, von Frey. Initially, some received 20-mg/kg loading dose This regimen caused severe morbidity mortality 2 Subsequently, this was abandoned, assigned group 10-mg/kg showed less tightening between 3 6 reduced frequency posture compared either saline. significantly mobile regardless treatment. These data indicate provides better than 2.5-mg/kg but does not completely alleviate pain.