Preparation and evaluation of bioavailability of gatifloxacine-loaded nanoparticles

• DOI: 10.3103/s0027131411020039
• Publication Date: 2011-05-24T00:07:56Z
• Authors: E. V. Blynskaya; K. V. Alekseev; S. E. Kondakov; R. N. Alyautdin; V. Yu. Balaban’yan
• Keywords: Glycolic acid

Pharmacokinetics of nanoparticles loaded with the antituberculosis drug gatifloxacine, as a new delivery system, was studied. In vivo experiments performed in laboratory animals showed that the dosage form of gatifloxacine incorporated into nanoparticles of poly(DL-lactic-co-glycolic acid) has a different pharmacological pattern as compared with the dosage form manufactured in industry. An increase in half-life (T1/2) and in mean residence time (MRT) was observed for gatifloxacine nanoparticles in blood plasma. The area under the “concentration versus time” pharmacological curve (AUC(0→36) was shown to increase mostly owing to the terminal part of the curve.