Innate receptors and IL-17 in the immune response against human pathogenic fungi

• DOI: 10.31053/1853.0605.v73.n3.13353
• Publication Date: 2020-02-20T18:20:01Z
• Authors: María Soledad Miró; Cecilia Vigezzi; Emilse Rodriguez; Paula Alejandra I...; Juan Pablo Caeiro; Fernando Oscar Riera; Diana Teresa Masih; Claudia Elena Sot...
• Keywords: 0301 basic medicine; Medicine (General); Inflammasomes; Macrophages; Interleukin-17; R; Fungi; Immunity, Innate; 3. Good health; 03 medical and health sciences; R5-920; Human fungal infections, antifungal immunity, innate receptors, Dectin-1, Inflamasommes, IL-17; Receptors, Pattern Recognition; Leukocytes; Medicine; Humans

In recent years, the rise of human fungal infections has been associated to lack early diagnosis, uneffective antifungal therapies and vaccines. Disturbance in immune homeostasis, which can be caused by medical interventions immunosuppression induced disease, are well known as risk factors for these pathologies. Cells innate system equipped with surface cytoplasmic receptors recognition microorganisms called pattern (PRRs). PRRs recognize specific pathogen-associated molecular patterns (PAMPs) that crucial activation killing pathogenic fungi system. This review will outline cells required effective immunity, a special focus on major cytokine IL-17. Finally, naturally occurring mutations involved increased susceptibility also discussed