Changes in Extent of Ulcerative Colitis A Study on the Course and Prognostic Factors

• DOI: 10.3109/00365529609004876
• Publication Date: 2007-11-20T13:21:46Z
• Authors: E. Langholz; P. Munkholm; M. Davidsen; O. H. Nielsen; V. Binder
• Keywords: Pancolitis; Sigmoidoscopy

AbstractBackground: The prognosis of patients with ulcerative colitis (UC) has previously been described regard to mortality, cancer occurrence, and need for colectomy on the basis an annual follow-up a regional cohort UC in Copenhagen County diagnosed 1962–87. objective this study was examine spread disease evaluate possible prognostic factors by multivariate regression analysis. Methods: An inception 1161 examined actuarial analysis subgroup 467 1979–87. Results: probability further progression proctosigmoiditis, evaluated sigmoidoscopy radiology, 53% after 25 years. 76.8% substantial 75.7% pancolitis Multivariate showed that occurrence symptoms abdominal pain diarrhoea prognostically unfavourable from proctosigmoiditis. Age influenced extensive disease. With following variables prognosis: fever, general condition, serum albumin, mucopus stools, at onset. Conclusion: Disease extent is not static but changes time approximately half patients. This finding should have implications follow-up. Ulcerative proctitis be considered same as needs long-term follow-up.Key Words: coursedisease extentmultivariate analysisprognosisulcerative