Procyanidins protects against oxidative damage and cognitive deficits after traumatic brain injury

• DOI: 10.3109/02699052.2014.968621
• Publication Date: 2014-10-03T15:49:13Z
• Authors: Xiang Mao; Shuyu Hao; Zhendan Zhu; Hao Zhang; Weichuan Wu; Feifan Xu; Baiyun Liu
• Keywords: Malondialdehyde; Brain damage

AbstractPrimary objective: Oxidative stress is the principal factor in traumatic brain injury (TBI) that initiates events result protracted neuronal dysfunction and remodeling. Importantly, antioxidants can protect against oxidative damage modulate capacity of to cope with synaptic cognitive impairment.Research design: To date, however, no studies have investigated effects procyanidins (PC) on deficits after TBI. Methods Procedures: In present study, rats controlled cortical impact (CCI) were used investigate protective procyanidins.Main outcomes results: The results showed reduced level malondialdehyde (MDA) elevated glutathione (GSH) activity superoxide dismutase (SOD). addition, treatment procyanidins, which levels brain-derived neurotropic (BDNF), phosphorylation-cAMP-response element binding protein (pCREB), total CREB, cyclic AMP (cAMP), improved performance Morris water maze TBI.Conclusions: These suggest appear counteract behavioral TBI through antioxidant up-regulation cAMP/CREB signaling.KeywordsAntioxidantCREBhippocampusoxidative stressprocyanidinsTBI AcknowledgementsWe would like express our gratitude Mr Ming Sun for his help.Declaration interestThe authors report conflict interests related this study or findings specified paper. This was supported by National Natural Science Foundation China (No.81171144), Beijing Nova program (No.XX2012033) Key Technology Research Development Program Ministry China(2013BAI09B03).