Percutaneous radiofrequency ablation (RFA) or robotic radiosurgery (RRS) for salvage treatment of colorectal liver metastases

• DOI: 10.3109/0284186x.2013.766362
• Publication Date: 2013-02-14T14:43:20Z
• Authors: Sebastian Stintzing; Alexander Grothe; Saskia Hendrich; Ralf-Thorsten Hof...; Volker Heinemann; Markus Rentsch; Christoph Fuerweger; Alexander Muacevic; Christoph G. Trumm
• Keywords: Adult; Aged, 80 and over; Male; Salvage Therapy; Liver Neoplasms; Robotics; Middle Aged; Radiosurgery; 3. Good health; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; Catheter Ablation; Humans; Female; Colorectal Neoplasms; Aged; Retrospective Studies

Background. Stereotactic radiation therapy is an evolving modality to treat otherwise unresectable liver metastases. In this analysis, two local therapies: 1) single session robotic radiosurgery (RRS) and 2) percutaneous radiofrequency ablation (RFA) were compared in a total of 60 heavily pretreated colorectal cancer patients. Methods. Thirty patients with 35 metastases not qualifying for surgery that treated curative intent RRS prospectively followed. To compare efficacy both treatment modalities, RFA during the same period time matched according number size lesions. Local tumor control, disease free survival (DFS), freedom from distant recurrence (FFDR) analyzed efficacy. Treatment-related side effects recorded comparison. Results. The median diameter lesions was 33 mm (7–53 mm). Baseline characteristics did differ significantly between groups. One- two-year control rates showed no significant difference but favored (85% vs. 65% 80% 61%, respectively). A longer DFS (34.4 months 6.0 months; p < 0.001) found. Both, FFDR (11.4 7.1 = 0.25) rate (67% 63% RFA, > 0.99) comparable. Conclusion. Single safe effective method trend towards seen when RFA.