Association between quality of life and clinical parameters in patients with myeloproliferative neoplasms

• DOI: 10.3109/10428194.2011.619608
• Publication Date: 2011-09-02T09:22:13Z
• Authors: Peter Johansson; Ruben Mesa; Robyn Scherber; Johanna Abelsson; Jan Samuelsson; Gunnar Birgegård; Björn Andréasson
• Keywords: Myeloproliferative neoplasm

The Myeloproliferative Neoplasm Symptom Assessment Form (MPN-SAF) is a validated quality of life (QoL) instrument. In our Swedish cohort 114 patients the symptomatic burden was found to be severe, with fatigue reported in 88% and reduced QoL majority patients. Patients primary myelofibrosis had highest scores, low QoL, for most MPN-SAF items, compared polycythemia vera essential thrombocythemia. Higher age showed significant associations BFI (Brief Fatigue Inventory) score, early satiety, concentration problems, dizziness, insomnia, cough weight loss. Blood values, disease duration myelosuppressive treatment did not significantly associate any exception higher hemoglobin, which correlated sad mood. Male MPN scored as regards sexual problems loss female Overall, valid instrument assessing among this population.