Evaluation ofFactor V Leiden, Prothrombin G20210A, MTHFR C677TandMTHFR A1298Cgene polymorphisms in retinopathy of prematurity in a Turkish cohort

• DOI: 10.3109/13816810.2015.1126611
• Publication Date: 2016-03-28T17:04:16Z
• Authors: Hatip Aydin; Murat Gunay; Gokhan Celik; Betul Onal Gunay; Umeyye Taka Aydin; Ali Karaman
• Keywords: Prothrombin G20210A; Turkish population; Factor V

Background: To assess Factor V Leiden (FVL) (rs6025), Prothrombin G20210A (rs1799963), MTHFR C677T (rs1801133), and A1298C (rs1801131) gene mutations as risk factors in the development of retinopathy prematurity (ROP).Materials methods: A total 105 children were included this cross-sectional study. Patients divided into two groups. The study group consisted 55 infants with a history ROP control comprised 50 healthy term birth. All subjects screened for presence certain (FVL, G20210A, A1298C) by Real-Time PCR at 1 year age.Results: mean gestational age (GA) birth weight (BW) were, 28.65 ± 2.85 weeks 1171 385.74 g, respectively. There no significant differences genotype allele frequency between groups (p > 0.05). Eight (14.5 %) had heterozygous one child (1.8%) homozygous FVL mutation group. One (2%) mutation. was statistically frequencies < 0.05).Conclusions: prevalence polymorphism (16.3 higher patients than Turkish cohort. We suggest possible association end