Flaxseed Protects Against Diabetes-Induced Glucotoxicity by Modulating Pentose Phosphate Pathway and Glutathione-Dependent Enzyme Activities in Rats

• DOI: 10.3109/19390211.2015.1036188
• Publication Date: 2015-11-25T23:34:33Z
• Authors: Müslüm Gök; Nuray N. Ulusu; Nilay Tarhan; Can Tufan; Gülgün Ozansoy; Nuray Arı; Çimen Karasu
• Keywords: Blood Glucose; 0301 basic medicine; Phosphogluconate Dehydrogenase; Body Weight; Glucosephosphate Dehydrogenase; Glutathione; Antioxidants; Diabetes Mellitus, Experimental; 3. Good health; Diabetes Complications; Pentose Phosphate Pathway; Oxidative Stress; 03 medical and health sciences; Glutathione Reductase; Flax; Seeds; Animals; Hypoglycemic Agents; Female; Plant Preparations; Rats, Wistar; Transaminases; Triglycerides

This study investigated the effects of flaxseed (Linum usitatissimum L.) intake on general metabolism, pentose phosphate pathway (PPP) and glutathione-dependent enzymes in diabetic rats. Diabetes was induced by streptozotocin injection (40 mg/kg, i.p.) enzyme activities were determined spectrophotometrically. Diabetic control rats divided two subgroups, one untreated, treated with (0.714 g/kg body weight/day; orally) for 12 weeks. Flaxseed ameliorated decreased weight (p < .05) increased blood glucose .001), triglyceride ALT .001) AST resulted glucose-6-phosphate dehydrogenase (G6PD) glutathione-S-transferase (GST) .01), but unchanged 6-phosphogluconate (6PGD) glutathione reductase (GR) brain These alterations partially improved comparison to untreated group .05). G6PD, 6PGD, GR elevated while GST lung compared control. prevented increase 6PGD unaffected G6PD .05), augmented, showed a significant depletion pancreas observed pancreatic significantly flaxseed. Furthermore, remarkable decrease an (threefold control) found lens that completely .001). has beneficial against diabetes-induced glucotoxicity modulating tissues.