Sensory recovery following decellularized nerve allograft transplantation for digital nerve repair

• DOI: 10.3109/2000656x.2013.778862
• Publication Date: 2013-07-15T08:22:39Z
• Authors: Yang Guo; Gary Chen; Guanglei Tian; Carla Tapia
• Keywords: Adult; Male; Adolescent; Tissue Engineering; Recovery of Function; Allografts; Nerve Regeneration; 3. Good health; Fingers; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Peripheral Nerve Injuries; Finger Injuries; Humans; Nerve Tissue; Retrospective Studies

This study reported preliminary clinical experience of using decelluarised nerve allograft material for repair of digital nerve defect in five hand injury patients. From October 2009 to July 2010, five patients with traumatic nerve defect were treated with nerve repair using AxoGen® nerve allograft (AxoGen Inc, Alachua, FL) in California Hospital Medical Center. All patients were followed at least for 12 months, and sensory recovery and signs of infection or rejection were documented by a hand therapist. Average two-point discrimination was 6 mm, and average Semmes-Weinstein Monofilaments test was 4.31. No wound infections or signs of rejections were observed at wound site. All patients reported sensory improvement during the follow-up period after operation. It is believed that decellularised nerve allografts may provide a readily available option for repair of segmental nerve defect.