The Levels of Soluble CD40 Ligand and C-Reactive Protein in Normal Weight, Overweight and Obese People

• DOI: 10.3121/cmr.2010.889
• Publication Date: 2010-07-26T23:09:34Z
• Authors: I. T. Unek; F. Bayraktar; D. Solmaz; H. Ellidokuz; A. R. Sisman; F. Yuksel; S. Yesil
• Keywords: Adult; Aged, 80 and over; Male; 2. Zero hunger; CD40 Ligand; Middle Aged; Overweight; Body Mass Index; 3. Good health; 03 medical and health sciences; C-Reactive Protein; 0302 clinical medicine; Humans; Female; Obesity; Aged

Obesity has been suggested as an independent risk factor for cardiovascular disease. Increasing evidence shows that engagement of soluble CD40 ligand (sCD40L) with its receptor plays a crucial role in the pathogenesis atherosclerosis. The aim present study was to test whether obesity is associated low-grade systemic inflammation measured by serum high-sensitive C-reactive protein (hsCRP) and sCD40L concentration.Serum hsCRP concentrations were 148 nondiabetic people. participants divided into three groups depending upon their body mass index (BMI) levels: Group 1 (normal weight), BMI<25 kg/m(2); 2 (overweight), BMI 25 kg/m(2) 29.9 3 (obese), BMI>or=30 kg/m(2).Obese people had more elevated levels than both normal weight overweight counterparts (P=0.000 P=0.000, respectively). Similarly, significantly higher, statistically, obese subjects compared (P=0.003). In addition, higher values subjects, but difference did not reach statistical significance (P=0.063). high-density lipoprotein cholesterol lower (P=0.048). analysis platelet count disclosed statistically significant between (P=0.028). positively correlated all (r=0.514, P=0.000 r=0.283, Levels waist circumference, fasting glucose, total cholesterol, triglyceride, low-density leukocytes, platelets, systolic diastolic blood pressure. CD40L glucose leukocytes.Obese patients showed increase which might contribute known proinflammatory milieu found these patients.