Efficacy and safety of Guduchighan Vati in asymptomatic and mild to moderate cases of COVID-19: A randomized controlled pilot study

• DOI: 10.31219/osf.io/c8f9h
• Publication Date: 2021-03-12T09:36:53Z
• Authors: Umesh Shukla; Nitin Ujjaliya; Pankaj Gupta; Vivek Khare; Babita Yadav; Amit Kumar Rai; Hetalben Amin; Rakesh Rana; Arunabh Tripathi; Bhagwan S Sharma; Shruti Khanduri; Bhogavalli Chandr...; N. Srikanth; Kartar Singh Dhiman
• Keywords: 0301 basic medicine; 0303 health sciences; 03 medical and health sciences; 16. Peace & justice; 3. Good health

Background: Currently, there is no approved treatment for the management of COVID-19 pandemic. Drug repurposing existing medications could be a possible way to find out novel therapeutic entity combat COVID-19.Objectives: To determine clinical effectiveness and safety profile an Ayurveda Intervention (Guduchighan Vati) in asymptomatic mild moderate cases COVID-19.Methods: This was open-label randomized controlled pilot study with sample size 30 participants (15 each arm). The were or COVID-19. Guduchighan Vati 500 mg twice daily 10 days administered intervention group as standalone therapy Hydroxychloroquine control group.Outcome measures: Time negative RT-PCR COVID-19, proportion turned at 5th 10th day, duration achieve complete recovery, improvement laboratory parameters incidence Adverse Reaction/Adverse Event. data compared within using paired t-test/ Wilcoxon signed rank test between independent t-test/Mann-Whitney test. results chi-square test.Results: 93.3% group, 66.6% till day period. However, are statistically insignificant (p = 0.068) which might attributed smaller size. All symptomatic patients clinically recovered whereas 14 15 group. No symptoms observed both groups. adverse drug reaction/serious event during period.Conclusion: safe effective it lowers time status without any reaction/adverse event.