Targeted Delivery of Controlled Release Nanoparticles to Brain Tumors Using Contrast Agent Microbubbles and High-Intensity Focused Ultrasound

• DOI: 10.31225/osf.io/7k5ab
• Publication Date: 2018-07-02T11:53:03Z
• Authors: Richard J. Price
• Keywords: Focused Ultrasound; High-intensity focused ultrasound; Brain tumor

High-Intensity Focused Ultrasound (HIFU) treatment of brain tumors is complicated by heating the skull. Here, our goal to overcome this limitation developing an ultrasound-microbubble-based therapeutic approach that complements HIFU mechanically-damaging tumor tissue, occluding blood flow, and depositing 5-FU bearing controlled-release nanoparticles into at reduced power levels. Experiments for monitoring nanoparticle delivery, flow changes, regression will be performed using implanted in mouse dorsal skinfold window chambers. We anticipate these studies result successful development a delivery method agent(s) suitable preclinical testing with HIFU.