Why, where and how do top-down and bottom-up signals interact in the primate brain?

• DOI: 10.31234/osf.io/7mryq_v1
• Publication Date: 2025-03-14T14:05:27Z
• Authors: Yujie Hou; Julien Vezoli; Kenneth Knoblauch; Rainer Göbel; Martin Vinck; Henry Kennedy
• Keywords: Human brain

Hierarchical predictive coding theory (hPC) proposes that perception arises from the integration of bottom-up (BU) pathways carrying sensory evidence with top-down (TD) carring priors and expectations. However, there is surprising little concerning location functional mechanisms underlying such BU-TD integration. This can be overcome by future parallel experiments in humans non-human primates (NHPs). Molecular characterization NHP cortico-cortical BU TD projection cell types will allow tracing these circuits exerting causal control to explore visual paradigms behaving NHPs. Identical human subjects undergoing ultra-high field laminar fMRI scanning indicate homologous brain access perceptual reports. In human, long-distance expectations suggest claustrum might involved hPC. Recent connectomic transcriptomic characterisation cortical-claustral-cortical loops enable a similar approach participation signals as used pathways.