Mega-Analysis Methods in ENIGMA: The Experience of the Generalized Anxiety Disorder Working Group

• DOI: 10.31234/osf.io/n62vc
• Publication Date: 2020-03-02T00:41:17Z
• Authors: André Zugman; Anita Harrewijn; Elise Cardinale; Hannah Zwiebel; Gabrielle Felice ...; Katy E. Werwath; Janna Marie Bas-H...; Nynke A. Groenewold; M. Aghajani; Kevin Hilbert; Narcis Cardoner; Daniel Porta-Cast...; Savannah Gosnell; Ramiro Salas; Karina S. Blair; James R. Blair; Mira Z. Hammoud; Mohammed Milad; Katie Burkhouse; K Luan Phan; Heidi K. Schroeder; Jeffrey R. Strawn; Katja Beesdo-Baum; Sophia I Thomopoulos; Hans J. Grabe; Sandra Van der Au...; Katharina Wittfeld; Jared Nielsen; Randy Buckner; Jordan W. Smoller; Benson Irungu; Jair Soares; Mon-Ju Wu; Giovana B. Zunta-...; Andrea P. Jackowski; Pedro Pan; Giovanni Salum; Michal Assaf; Gretchen J. Diefe...; Paolo Brambilla; Eleonora Maggioni; David Hofmann; thomas straube; Carmen Andreescu; Rachel Berta; Erica Tamburo; Rebecca Price; Gisele Gus Manfro; HUgo Critchley; Elena Makovac; Matteo Mancini; Frances Meeten; Cristina Ottaviani; Federica Agosta; Elisa Canu; Camilla Cividini; Massimo Filippi; Milutin Kostić; Ana Munjiza; Courtney A Filippi; Ellen Leibenluft; Bianca A. V. Albe...; Nicholas L. Balde...; Monique Ernst; Christian Grillon; Lilianne R Mujica...; Helena van Nieuwe...; Gregory Fonzo; Martin P Paulus; Murray B. Stein; Raquel E. Gur; Ruben C. Gur; Antonia N. Kaczku...; Bart Larsen; Theodore D. Satte...; Jennifer Harper; Michael Myers; Michael T. Perino; Chad M. Sylvester; Qiongru Yu; Dick J. Veltman; Ulrike Lueken; Nic van der Wee; Dan J. Stein; Neda Jahanshad; Paul Thompson; Daniel S. Pine; Anderson M. Winkler
• Keywords: Mega-; Group analysis

The ENIGMA group on Generalized Anxiety Disorder (ENIGMA-Anxiety/GAD) is part of a broader effort to investigate anxiety disorders using imaging and genetic data across multiple sites worldwide. actively conducting mega-analysis large number brain structural scans. In this process, the was confronted with many methodological challenges related study planning implementation, between-country transfer subject-level data, quality control considerable amount choices statistical methods efficient use resources. This report summarizes background information rationale for various decisions, as well approach taken implement them. goal document help guide other research groups working sets they develop their own analytic pipelines mega-analyses.