Ceruloplasmin, a potential marker for glycemic status and its relationship with lipid profile in Type II diabetes mellitus

• DOI: 10.3126/ajms.v9i2.19003
• Publication Date: 2018-03-01T09:52:01Z
• Authors: Vijay Kumar Sharma; Arjun Tumbapo; Vivek Pant; Binod Aryal; Sweta Shrestha; Binod Kumar Yadav; Eans Tara Tuladhar; Aseem Bhattarai; Mithileshwor Raut
• Keywords: Ceruloplasmin; Lipid Profile

Background: Type II Diabetes Mellitus (Type DM) is a metabolic disorder characterized by glucotoxicity and lipotoxicity. Marker of glycemic control are HbA1c, fasting blood glucose postprandial glucose. There altered lipid parameters in DM which possess significant cardiovascular risk to the patient. Recent studies have shown that ceruloplasmin, an inflammatory marker having antioxidant property,is ideal know status, degree insulin resistance cancer risk.Aims Objectives: Present study was carried out determine relation between status serum ceruloplasmin along with reflects these patients.Materials Methods: Blood samples were collected from eighty-eight patients type diabetes mellitus age sex matched forty-two healthy controls. Fasting profile glucose, HbA1c levels determined using auto analyser department clinical biochemistry Institute Medicine.Appropriate tests significance computed SPSS version 20.Results: Serum found higher than non-diabetic group, median 52.0 (95% CI: 49-53) mg/dl versus 45.0 41-47) mg/dl, at level 0.001 probability test. Similarly, post prandial TG/HDL cholesterol ratio correlated significantly ceruloplasmin.The cut off value 46.5 mg/dL obtained for sensitivity 87.5% specificity 62% has good discriminating diabetic patients.Conclusion: Findings our shows increased glycation coupled causes enhanced generation could be used as potential identifying acceleratedglycation atherogenesis subjects.Asian Journal Medical Sciences Vol.9(2) 2018 13-18