A Meta-Analysis of Remote Ischemic Preconditioning in Lung Surgery and Its Potential Role in COVID-19

• DOI: 10.3138/ptc-2021-0031
• Publication Date: 2022-02-24T13:50:32Z
• Authors: Lawrence P. Cahalin; Magno F. Formiga; Johnny Owens; Brian M. Osman
• Keywords: Ischemic Preconditioning

Purpose: To determine the effects of remote ischemic preconditioning (RIPC) on pulmonary gas exchange in people undergoing surgery and discuss a potential role RIPC COVID-19. Method: A search for studies examining after was performed. RevMan used statistical analyses measures A-ado 2 , Pao /Fio respiratory index (RI), a/A ratio Paco obtained earlier (i.e., 6–8 hours) later 18–24 hours). Results: Four trials were included ( N = 369 participants). Significant p < 0.05) overall observed early RI (SMD −0.84 SMD −1.23, respectively), RI, −0.39, 0.72, 1.15, respectively) with approaching significance 0.05; −0.45). improvements inflammatory markers oxidative stress also observed. Conclusions: has to improve exchange, markers, lung disease receiving mechanical ventilation. These may be beneficial COVID-19, but further investigation is warranted.