Association of Genetic Polymorphisms in Base excision Repair Pathways and Cervical Cancer Risk Factors in a Tertiary Care Centre

• DOI: 10.31557/apjcb.2024.9.1.3-9
• Publication Date: 2024-04-04T06:02:10Z
• Authors: Mark Rector Charles; Syed Tasleem Raza; Pushpendra Pratap; Ale Eba
• Keywords: Tertiary care

Background and Objective: Cervical cancer is one of the most frequent neoplastic disorders affecting women, with about half a million new cases diagnosed globally each year. Reduced DNA repair capacity (DRC) linked to an increased risk cancer, particularly cervical cancer. gene polymorphisms may play role in genomic instability carcinogenesis. number factors that have been verified. The goal this study was compare genotypes genes XRCC1-194, XRCC1-280, XRCC1-399, XRCC3-241 distinct histological subtypes patients controls.Material Methods: To test theory, 168 confirmed 184 healthy control women inducted study. For genotyping we used CTPP method (Arg194Trp, Arg280His, Arg399Gln & XRCC3-T241M). Results: A positive association observed between XRCC1 genes, is, codons 194 [P=0.03, odds ratio (OR) =2.39, 95% confidence interval (CI)=5.2–1.1], 280 (P=0.01, OR=4.1, CI=11.5–1.3), 399 OR=3.4, CI=8.6–1.3) As well as factor like early age pregnancy, high parity are also likely be contributing disease development.Conclusion: Our results suggested that, XRCC1399 important candidate for susceptibility Although sample size small, present indicate statistical SNPs. Future studies needed provide better understanding polymorphism carcinoma assessed.