CXCL1, CXCL10 and CXCL12 Chemokines are Variously Expressed in Acute Myeloid Leukemia Patients Prior and Post Bone Marrow Transplantation

• DOI: 10.31557/apjcp.2021.22.10.3377
• Publication Date: 2021-10-29T05:30:23Z
• Authors: Bahar Yazdani; Gholamhossein Has...; Zahra Mousavi; Zahra Ahmadi; Hussein Khorramde...; Alireza Moradabadi; Mohamadreza Shafi...; Abbas Fatehi
• Keywords: CXCL1; CXCR3; Pathogenesis

The chemokine-receptor axes play parts in development of leukemia, CXCL1, CXCL10 and CXCL12 are involved immune responses. Thus, we have examined the serum levels these chemokines parallel with their related cognate receptors (CXCR1, CXCR3 CXCR4) AML (acute myeloid leukemia) patients prior post BMT (bone marrow transplantation) therapy.Clinical specimens were collected from 46 (23 M1 23 M3 subtypes) before/after BMT. concentrations determined by ELISA. mRNA detected QRT_PCR. Data analyzed T-test, χ2 ANOVA statistical methods SPSS software version 18. A difference was regarded significant if P value < 0.05.Our results indicated that elevated remained unchanged after transplantation. concentration decreased patients. All studied history 9 times PLT transfusion. In who received siblings CXCL1 been elevated, whereby they compared to parents while sustained groups. Serum measures induced acute chronic GVHD compare without GVHD.According results, it can be concluded fundamental pathogenesis both It is worthy note could used as diagnostic markers alongside possible promising therapeutic targets.