Treatment Outcome of Children with Retinoblastoma in a Tertiary Care Referral Hospital in Indonesia

• DOI: 10.31557/apjcp.2021.22.5.1613
• Publication Date: 2021-05-28T17:20:05Z
• Authors: Krisna Handayani; Braghmandita Indr...; Mei Sitaresmi; Sri Mulatsih; Pudjo Widjajanto; Wijnanda Kors; Gertjan Kaspers; Saskia Mostert
• Keywords: Medical record; Retinoblastoma

Background: Although survival rates for retinoblastoma (RB) are over 95% in high-income countries, its high mortality rate low and middle-income countries remains a great concern. Few studies investigated treatment outcome factors contributing to RB these latter settings. Aims of this study determine Indonesian children diagnosed with explore predictive outcome. Methods: This was retrospective medical records review combined an illustrative case report. Children newly between January 2011 December 2016 at tertiary care referral hospital Indonesia were included. A home visit conducted perform in-depth interview mother two affected by RB. Results: Of all 61 RB, 39% abandoned treatment, 21% died, 20% had progressive or relapsed disease event-free survival. Progressive more common older (≥ 2 years diagnosis, 29%) than young (<2 0%) (P=0.012). Event-free estimate 5 higher (42%) (6%) (P=0.045). Odds-ratio 6.9 (95% CI: 1.747 – 27.328, P=0.006) versus children. Other clinical socio-demographic characteristics no significant correlation The report elucidated conditions obstacles that families face when their Conclusion: Survival is much lower compared many other countries. Abandonment the most cause failure. Older age diagnosis associated worse Interventions improve general public health-care providers' awareness, early detection adherence required.