Bacterial cell wall components regulate adipokine secretion from visceral adipocytes

• DOI: 10.3164/jcbn.14-74
• Publication Date: 2015-01-07T22:05:33Z
• Authors: Risa Taira; Sayori Yamaguchi; Kyoko Shimizu; Kiminori Nakamura; Tokiyoshi Ayabe; Toshio Taira
• Keywords: Resistin

Recent studies suggest a relationship between intestinal microbiota and metabolic syndromes; however, the underlying mechanism remains unclear. To clarify this issue, we assessed effects of bacterial cell wall components on adiponectin, leptin resistin secretion from rat visceral adipocytes in vitro. We also measured relative population Firmicutes Bacteroidetes fecal amount mucin as an barrier function, when mice were fed high-fat diet. In present study, demonstrated that affect adipokines, depending presence antigens gram-positive or gram-negative bacteria. Lipopolysaccharide markedly inhibited leptin, secretion, whereas peptidoglycan increased adiponectin decreased vivo experiments showed diet Bacteroidetes. contrast, downregulated stool output content. These results demonstrate onset syndromes by mediating adipokines adipose tissue. Furthermore, believe endotoxemia is not due to increasing dominance bacteria, Bacteroidetes, but depression function.