Capabilities of fecal calprotectin and blood biomarkers as surrogate endoscopic markers according to ulcerative colitis disease type

• DOI: 10.3164/jcbn.18-92
• Publication Date: 2019-03-06T17:38:55Z
• Authors: Hiroki Sonoyama; Kousaku Kawashima; Shunji Ishihara; Satoshi Kotani; Nobuhiko Fukuba; Akihiko Oka; Ryusaku Kusunoki; Yasumasa Tada; Yoshiyuki Mishima; Naoki Oshima; Ichiro Moriyama; Takafumi Yuki; Koji Onishi; Yoshikazu Kinoshita
• Keywords: Erythrocyte sedimentation rate; Pancolitis

Fecal calprotectin level in ulcerative colitis patients is correlated with endoscopic findings. However, its association various disease types has not been elucidated. In the present study, we investigated correlation of fecal findings as compared to blood biomarkers according type. well biomarkers: C-reactive protein (CRP), white count (WBC), erythrocyte sedimentation rate (ESR), hemoglobin, platelet (PLT), and serum albumin (Alb) were measured who underwent a complete colonoscopy. Disease type was divided into proctitis, left-sided colitis, extensive colitis. Correlations biomarker levels Mayo subscore analyzed. A total 186 colonoscopy examinations performed 124 showed significant regardless (proctitis, r = 0.54, p<0.01; 0.75, 0.78, p<0.01), clearly discriminated inactive (Mayo 0) from active stages 1-3). On other hand, none examined proctitis group, while weak correlations several (CRP, WBC, ESR, PLT Alb) found cases. This first report elucidate capabilities surrogate markers