Experimental vasoconstriction of cerebral arteries by prostaglandins

• DOI: 10.3171/jns.1972.37.4.0385
• Publication Date: 2009-05-07T14:40:41Z
• Authors: Y. Lucas Yamamoto; William Feindel; Leonhard S. Wolfe; Hiroko Katoh; Charles P. Hodge
• Keywords: Cerebral circulation; Cerebral Vasospasm

✓ Effects of intracarotid infusion prostaglandins (PG) E 1 and F 2 a on the circulation to dog brain were examined by fluorescein angiography, measuring diameter changes in epicerebral vessels, microregional cerebral blood flow with 133 xenon lithium-drift silicon detectors. PGE at doses 0.5 µg/min constricted arteries 700 µ or less diameter, arrested dye injected into carotid system, reduced rCBF 42% increase collateral vertebrobasilar system. This effect was not obtained which 0.08% ethanol had been added. PGF 25 arterial vessels than 200 35%, decreased cortical microcirculation lengthening time. Selective clipping external internal indicated that acts constricting these as well arteries. Since are released from platelets stimulation cortex they should be considered factors involved regulation mechanism vasospasm. These properties also imply need for caution when substances used clinical investigation.