The effect of brain temperature on hemoglobin extravasation after traumatic brain injury

• DOI: 10.3171/jns.2002.97.4.0945
• Publication Date: 2009-05-13T17:45:47Z
• Authors: Kosaku Kinoshita; Katina Chatzipanteli; Ofelia F. Alonso; Mackenzie Howard; W. Dalton Dietrich
• Keywords: Male; Fever; Severity of Illness Index; Body Temperature; Rats; Rats, Sprague-Dawley; Hemoglobins; 03 medical and health sciences; 0302 clinical medicine; Hypothermia, Induced; Spectrophotometry; Brain Injuries; Cerebral Hemorrhage, Traumatic; Animals

Object. Although the benefits of posttraumatic hypothermia have been reported in experimental studies, potential for therapeutic to increase intracerebral hemorrhage remains a clinical concern. The purpose this study was quantify amount extravasated hemoglobin after traumatic brain injury (TBI) and assess changes concentrations under hypothermic hyperthermic conditions. Methods. Intubated anesthetized rats were subjected fluid-percussion (FPI). In first experiment, divided into moderate (1.8–2.2 atm) severe (2.4–2.7 TBI groups. second effects 3 hours (33 or 30°C), hyperthermia (39°C), normothermia (37°C) on levels following trauma assessed. perfused with saline at 24 postinjury, then traumatized contralateral hemispheres, including cerebellum, dissected from whole brain. level each quantified using spectrophotometric assay. results these assays indicate that FPI induce increased ipsilateral hemisphere (p < 0.0001). After TBI, concentration also significantly 0.05) cerebellum 0.005). Posttraumatic (30°C) attenuated 0.005) hemisphere, whereas had marked adverse effect Conclusions. Injury severity is an important determinant degree extravasation TBI. reduced extravasation, compared normothermia. These findings are consistent previous data reporting temperature manipulations alter cerebrovascular inflammatory consequences