A patient-specific computer model to predict outcomes of the balloon occlusion test

• DOI: 10.3171/jns.2004.101.6.0977
• Publication Date: 2009-05-13T18:03:03Z
• Authors: Fady T. Charbel; Meide Zhao; Sepideh Amin-Hanjani; William Hoffman; Xinjian Du; Marlyn E. Clark
• Keywords: Digital subtraction angiography; Stroke; Posterior cerebral artery

Object. Balloon occlusion tests (BOTs) are performed to identify patients who at risk for ischemia and stroke following permanent internal carotid artery (ICA) occlusion. The object of this work was determine whether patient-specific blood flow modeling can be used in whom the BOT would not tolerated. Methods. test 16 underwent with continuous neurological electroencephalographic monitoring, followed by a hypotensive challenge. During hypotension tracer injected so that single-photon emission tomography (SPECT) scans could obtained. Each individual brain circulation modeled using information gained from phase-contrast magnetic resonance (MR) angiography digital subtraction (DS) angiography, predicted effect evaluated. Six did tolerate BOT; these patients, decreases middle cerebral (M 1 segment) 41 ± 27% (mean standard deviation), anterior (A 3 56 33%, posterior (P 2 4 13% ipsilateral site were found modeling; changes significantly greater than percentage measured contralateral hemisphere (p < 0.05). Ten tolerated well had calculated flows only 9 6% M segment, 12 40% A 17 21% P segment during modeling. Conclusions. decrease both segments 20%, BOT, 100% sensitive specific identifying BOT. Blood modeling, coupled DS noninvasive MR measurements make calculations patient specific, have an elevated