Diagnostic value of thallium-201 chloride single-photon emission computerized tomography in differentiating tumor recurrence from radiation injury after gamma knife surgery for metastatic brain tumors

• DOI: 10.3171/jns.2005.102.s_supplement.0266
• Publication Date: 2009-05-13T18:11:12Z
• Authors: Toru Serizawa; Naokatsu Saeki; Yoshinori Higuchi; Junichi Ono; Shinji Matsuda; Makoto Sato; Masamichi Yanagisawa; Toshihiko Iuchi; Osamu Nagano; Akira Yamaura
• Keywords: Thallium; Brain tumor; Emission computed tomography

Object. The authors assessed the diagnostic value of 201 Tl Cl single-photon emission computerized tomography (SPECT), performed after gamma knife surgery (GKS) for metastatic brain tumors in differentiating tumor recurrence from radiation injury. Methods. Of 6503 treated with GKS, SPECT was required 72 to differentiate between and When index greater than 5, lesion diagnosed as a recurrence. < 3.0 it called In cases 3 repeated once per month until 5 or less 3. If fluctuated 2 months, final diagnosis based on histological examination clinical course. sensitivity method 91%; thus is effective injury GKS. Caution necessary, however, following reasons: 1) simple interinstitutional comparisons indices are not possible because measurement methods institute specific; 2) steroid administration decreases variable degree; 3) severe lesion, often seen GKS very high dose may have 5. Conclusions. Used critical insight can be useful distinguishing regrowth necrosis patients cerebral metastases.