Safety and efficacy of a novel polyethylene glycol hydrogel sealant for watertight dural repair

• DOI: 10.3171/jns.2007.106.1.52
• Publication Date: 2008-01-24T12:45:25Z
• Authors: G. Rees Cosgrove; Johnny B. Delashaw; J. Andre Grotenhuis; John M. Tew; Harry van Loveren; Robert F. Spetzler; Troy Payner; Gail Rosseau; Mark E. Shaffrey; L. Nelson Hopkins; Richard Byrne; Alex Norbash
• Keywords: Cerebrospinal Fluid Leakage; Cerebrospinal fluid leak

Object The authors prospectively evaluated the safety and efficacy of a novel polyethylene glycol (PEG) hydrogel sealant in patients undergoing elective cranial surgery with documented cerebrospinal fluid (CSF) leakage after sutured dural repair. Methods PEG was used at 11 different study sites 111 intraoperative CSF neurosurgical repair for variety conditions. Intraoperative either spontaneous or induced by Valsalva maneuver. Patients were monitored 3 months postoperatively physical examinations, clinical laboratory analyses, diagnostic imaging. 100% effective stopping all patients. There no sealant-related adverse events outcomes consistent expectations seriously ill prolonged procedures. Conclusions provides safe watertight closure when as an adjunct to during surgery.