Primary Cerebral Lymphoma and Glioblastoma Multiforme: Differences in Diffusion Characteristics Evaluated with Diffusion Tensor Imaging

• DOI: 10.3174/ajnr.a0872
• Publication Date: 2007-12-07T20:45:19Z
• Authors: C.-H. Toh; M. Castillo; A.M.-C. Wong; K.-C. Wei; H.-F. Wong; S.-H. Ng; Y.-L. Wan
• Keywords: Adult; Aged, 80 and over; Male; Lymphoma; Brain Neoplasms; Brain; Reproducibility of Results; Middle Aged; Sensitivity and Specificity; Diagnosis, Differential; 03 medical and health sciences; Diffusion Magnetic Resonance Imaging; 0302 clinical medicine; Image Interpretation, Computer-Assisted; Humans; Female; Glioblastoma; Aged

<b>BACKGROUND AND PURPOSE:</b> Differentiating between primary cerebral lymphoma and glioblastoma multiforme (GBM) based on conventional MR imaging sequences may be impossible. Our hypothesis was that there are significant differences in fractional anisotropy (FA) apparent diffusion coefficient (ADC) GBM, which will allow for differentiation them. <b>MATERIALS METHODS:</b> Preoperative tensor (DTI) performed 10 patients with GBM. Regions of interest were placed only solid-enhancing tumor areas the contralateral normal-appearing white matter (NAWM) to measure FA ADC values. The as well each type NAWM, analyzed statistically. Cutoff values FA, ratio, ADC, ratio distinguishing lymphomas from GBMs determined by receiver operating characteristic curve analysis. <b>RESULTS:</b> significantly decreased compared NAWM. Mean (×10⁻³ mm²/s), ratios 0.140 ± 0.024, 0.25 0.04, 0.630 0.155, 0.83 0.14 lymphoma, respectively, 0.229 0.069, 0.40 0.12, 0.963 0.119, 1.26 0.13 respectively. All different differentiate GBM 0.192 0.33 0.818 1.06 ratio. <b>CONCLUSIONS:</b> lower than those DTI is able