Primary Cerebral Lymphoma and Glioblastoma Multiforme: Differences in Diffusion Characteristics Evaluated with Diffusion Tensor Imaging
Adult
Aged, 80 and over
Male
Lymphoma
Brain Neoplasms
Brain
Reproducibility of Results
Middle Aged
Sensitivity and Specificity
Diagnosis, Differential
03 medical and health sciences
Diffusion Magnetic Resonance Imaging
0302 clinical medicine
Image Interpretation, Computer-Assisted
Humans
Female
Glioblastoma
Aged
DOI:
10.3174/ajnr.a0872
Publication Date:
2007-12-07T20:45:19Z
AUTHORS (7)
ABSTRACT
<b>BACKGROUND AND PURPOSE:</b> Differentiating between primary cerebral lymphoma and glioblastoma multiforme (GBM) based on conventional MR imaging sequences may be impossible. Our hypothesis was that there are significant differences in fractional anisotropy (FA) apparent diffusion coefficient (ADC) GBM, which will allow for differentiation them. <b>MATERIALS METHODS:</b> Preoperative tensor (DTI) performed 10 patients with GBM. Regions of interest were placed only solid-enhancing tumor areas the contralateral normal-appearing white matter (NAWM) to measure FA ADC values. The as well each type NAWM, analyzed statistically. Cutoff values FA, ratio, ADC, ratio distinguishing lymphomas from GBMs determined by receiver operating characteristic curve analysis. <b>RESULTS:</b> significantly decreased compared NAWM. Mean (×10<sup>−3</sup> mm<sup>2</sup>/s), ratios 0.140 ± 0.024, 0.25 0.04, 0.630 0.155, 0.83 0.14 lymphoma, respectively, 0.229 0.069, 0.40 0.12, 0.963 0.119, 1.26 0.13 respectively. All different differentiate GBM 0.192 0.33 0.818 1.06 ratio. <b>CONCLUSIONS:</b> lower than those DTI is able
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