Cerebral Blood Flow Improvement after Indirect Revascularization for Pediatric Moyamoya Disease: A Statistical Analysis of Arterial Spin-Labeling MRI

• DOI: 10.3174/ajnr.a4592
• Publication Date: 2016-01-11T17:25:11Z
• Authors: T. Blauwblomme; H. Lemaitre; O. Naggara; R. Calmon; M. Kossorotoff; M. Bourgeois; B. Mathon; S. Puget; M. Zerah; F. Brunelle; C. Sainte-Rose; N. Boddaert
• Keywords: Moyamoya Disease; Statistical parametric mapping; Arterial spin labeling; Magnetic resonance angiography

<h3>BACKGROUND AND PURPOSE:</h3> The severity of Moyamoya disease is generally scaled with conventional angiography and nuclear medicine. Arterial spin-labeling MR imaging now acknowledged for the noninvasive quantification cerebral blood flow. This study aimed to analyze CBF modifications statistical parametric mapping arterial in children undergoing an operation disease. <h3>MATERIALS METHODS:</h3> We included 15 treated by indirect revascularization multiple burr-holes between 2011 2013. T1 sequences were then analyzed under SPM8, according general linear model, before after (3 12 months). Voxel-based analysis was performed at group level, comparing all diseased hemispheres normal and, individual each patient a control group. <h3>RESULTS:</h3> Group showed statistically significant preoperative hypoperfusion MCA territory increase perfusion same (<i>P</i> &lt; .05 family-wise error–corrected). Before operation, co-localized angiographic defect on DSA. All except 1 had improvement revascularization, correlated their clinical status. <h3>CONCLUSIONS:</h3> SPM offers evaluation hemodynamic impairment objective assessment postoperative