The Cervical Spinal Canal Tapers Differently in Patients with Chiari I with and without Syringomyelia

• DOI: 10.3174/ajnr.a4597
• Publication Date: 2016-01-11T17:25:11Z
• Authors: A. Thompson; N. Madan; J.R. Hesselink; G. Weinstein; A. Munoz del Rio; V. Haughton
• Keywords: Adult; Male; Observer Variation; Aging; Sex Characteristics; Hernia; Reproducibility of Results; Magnetic Resonance Imaging; Spine; Syringomyelia; Arnold-Chiari Malformation; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Cervical Vertebrae; Humans; Female; Foramen Magnum; Spinal Canal; Encephalocele

The cause of syringomyelia in patients with Chiari I remains uncertain. Cervical spine anatomy modifies CSF velocities, flow patterns, and pressure gradients, which may affect the spinal cord. We tested the hypothesis that cervical spinal anatomy differs between Chiari I patients with and without syringomyelia.We identified consecutive patients with Chiari I at 3 institutions and divided them into groups with and without syringomyelia. Five readers measured anteroposterior cervical spinal diameters, tonsillar herniation, and syrinx dimensions on cervical MR images. Taper ratios for C1-C7, C1-C4, and C4-C7 spinal segments were calculated by linear least squares fitting to the appropriate spinal canal diameters. Mean taper ratios and tonsillar herniation for groups were compared and tested for statistical significance with a Kruskal-Wallis test. Inter- and intrareader agreement and correlations in the data were measured.One hundred fifty patients were included, of which 49 had syringomyelia. C1-C7 taper ratios were smaller and C4-C7 taper ratios greater for patients with syringomyelia than for those without it. C1-C4 taper ratios did not differ significantly between groups. Patients with syringomyelia had, on average, greater tonsillar herniation than those without a syrinx. However, C4-C7 taper ratios were steeper, for all degrees of tonsil herniation, in patients with syringomyelia. Differences among readers did not exceed differences among patient groups.The tapering of the lower cervical spine may contribute to the development of syringomyelia in patients with Chiari I.