Correlation between 2D and 3D Fetal Brain MRI Biometry and Neurodevelopmental Outcomes in Fetuses with Suspected Microcephaly and Macrocephaly

• DOI: 10.3174/ajnr.a7225
• Publication Date: 2021-08-12T15:00:36Z
• Authors: S. Fried; M. Gafner; D. Jeddah; N. Gosher; D. Hoffman; R. Ber; A. Mayer; E. Katorza
• Keywords: Macrocephaly; Microcephaly

Definitions of fetal microcephaly and macrocephaly are debatable. A better understanding their long-term prognoses would help guide parental education counseling. This study aimed to explore the correlation between 2D 3D brain MR imaging biometry results neurodevelopmental outcomes.This analysis is a historical cohort study. Fetal was measured on using volumetric semiautomated algorithm. We assessed following structures: supratentorial volume cerebellar volume/supratentorial ratio, in addition commonly used biometric variables, including occipitofrontal diameter, biparietal transcerebellar diameter. Microcephaly defined as ≤ 3rd percentile; macrocephaly, ≥ 97th percentile, corresponding -2 SDs +2 SDs. The outcome this evaluated Vineland-II Adaptive Behavior Scales, measurements were correlated Vineland standard scores.A total 70 fetuses included. No significant observed scores either volume, or volume/cerebellar ratio measurements, after correction for multiple comparisons. differences found among with normocephaly, regarding median scores.Provided there normal structure imaging, developmental milestone achievements early years unrelated biometry, range depicted