Phosphaturic Mesenchymal Tumor

• DOI: 10.3174/ajnr.a7513
• Publication Date: 2022-05-19T15:00:16Z
• Authors: J.C. Benson; J.A. Trejo-Lopez; A.M. Nassiri; K. Eschbacher; M.J. Link; C.L. Driscoll; R.D. Tiegs; J. Sfeir; D.R. DeLone
• Keywords: 0301 basic medicine; Neoplasms, Connective Tissue; 03 medical and health sciences; Paraneoplastic Syndromes; Osteomalacia; Humans; Mesenchymoma

Phosphaturic mesenchymal tumors (PMTs) are neoplasms associated with tumor-induced osteomalacia. Patients typically present with pathologic fractures in the setting of chronic hypophosphatemic hyperphosphaturic osteomalacia, as well as gradual muscle weakness, bone pain, and difficulty walking. Because of their rarity and nonspecific symptomatology, phosphaturic mesenchymal tumors often go undiagnosed for years. Even when discovered on imaging, the tumors can be diagnostically challenging for radiologists. Phosphaturic mesenchymal tumors often tend to be small and can be located nearly anywhere in the body, and, therefore, can mimic many other tumors. This case highlights the imaging and pathologic markers of a phosphaturic mesenchymal tumor, often found in a patient with tumor-induced osteomalacia.