Comparison of Volumetric and 2D Measurements and Longitudinal Trajectories in the Response Assessment ofBRAFV600E-Mutant Pediatric Gliomas in the Pacific Pediatric Neuro-Oncology Consortium Clinical Trial

• DOI: 10.3174/ajnr.a8189
• Publication Date: 2024-03-07T18:10:36Z
• Authors: Divya Ramakrishnan; Sarah C. Brüningk; Marc von Reppert; Fatima Memon; Nazanin Maleki; Sanjay Aneja; Anahita Fathi Kaz...; Ali Nabavizadeh; MingDe Lin; Khaled Bousabarah; Annette Molinaro; Theodore Nicolaides; Michael Prados; Sabine Mueller; Mariam S. Aboian
• Keywords: Proto-Oncogene Proteins B-raf; Treatment Outcome; Brain Neoplasms; Humans; Prospective Studies; Glioma; Child; Magnetic Resonance Imaging

<h3>BACKGROUND AND PURPOSE:</h3> Response on imaging is widely used to evaluate treatment efficacy in clinical trials of pediatric gliomas. While conventional criteria rely 2D measurements, volumetric analysis may provide a more comprehensive response assessment. There sparse research the role volumetrics Our purpose was compare and with assessment neuroradiologists using Brain Tumor Reporting Data System (BT-RADS) <i>BRAF</i> V600E-mutant <h3>MATERIALS METHODS:</h3> Manual segmentations whole solid tumors were compared measurements 31 participants (292 follow-up studies) Pacific Pediatric Neuro-Oncology Consortium 002 trial (NCT01748149). Two evaluated responses BT-RADS. Receiver operating characteristic classification performance for partial response. Agreement between mathematically modeled longitudinal trajectories 25 determined model-estimated time best <h3>RESULTS:</h3> Of participants, 20 had according BT-RADS criteria. curves responders at first detection (median = 2 months) yielded an area under curve 0.84 (95% CI, 0.69–0.99) area, 0.91 0.80–1.00) whole-volume, 0.92 0.82–1.00) volume change. no significant difference (<i>P </i>= .34) or .39). correlation (ρ 0.39, <i>P</i> &gt;.05) whole-volume trajectories. Eight ≥90 days transition from stable disease their <h3>CONCLUSIONS:</h3> Although there overall classifying BT-RADS, further prospective studies will be critical elucidate how observed differences tumor affect decision-making outcomes some individuals.