SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SPIROOXINDOLE-CHROMENE DERIVATIVE COMPOUNDS BASED CURCUMINOID AND CHALCONE

• DOI: 10.31788/rjc.2021.1435546
• Publication Date: 2021-09-09T09:56:39Z
• Authors: S. H. Oktavia; A. H. Cahyana; M. Hapsari; Rika Tri Yunarti; Agus Rimus Liandi
• Keywords: Chalcone; Curcuminoid; Isatin; Knoevenagel condensation

Multicomponent reactions (MCRs) are an efficient strategy to synthesize various heterocyclic compounds in one pot, and a simple step by combining the reactants same flask.In this study, series of spiro-oxindole substituted chromene rings were synthesized via Knoevenagel Micheal addition reaction using curcuminoid chalcone as precursors.The was assisted Nickel ferrite (NiFe2O4) nanocatalyst ethanol solvent at 70°C.NiFe2O4 co-precipitation method characterized FTIR, XRD, SEM-EDX.The two spirooxindole-chromene derivatives with NiFe2O4 their functional group vibrations molecular mass FTIR GCMS, respectively.Under conditions 5% (w/w) catalyst, yields compound 1 2 95% 90%.Only responded antibacterial activity test against gram-positive bacteria (Staphylococcus aureus Bacillus subtilis).