Interleukin 1 Enhances Synovial Cell Hyaluronate Synthesis

• DOI: 10.3181/00379727-177-1-rc1
• Publication Date: 2013-06-20T20:53:09Z
• Authors: D. Hamerman; D. D. Wood
• Keywords: Monocyte

Interleukin 1 enhances proliferation of murine thymocytes in the presence lectins, and is also known to stimulate release prostaglandins neutral proteases from a variety cell types. We have previously shown that factor isolated culture media disaggregated lining cells human synovial membrane was indistinguishable monocyte-derived interleukin 1. report here either source stimulates hyaluronate synthesis by cells. Upon gel filtration or isoelectric focusing superna-tants, hyaluronate-stimulatory activity co-fractionates with activity. Enhanced secretion newly described metabolic effect