Metabolism of N1-Acetylspermidine and N8-Acetylspermidine in Rats

• DOI: 10.3181/00379727-177-41930
• Publication Date: 2013-06-20T20:53:09Z
• Authors: J. Blankenship; P. E. Marchant
• Keywords: Male; 0301 basic medicine; Time Factors; Spermidine; Rats, Inbred Strains; Kidney; Models, Biological; Rats; 3. Good health; 03 medical and health sciences; Liver; Animals; Chromatography, High Pressure Liquid

Metabolism of N1-acetylspermidine and N8-acetylspermidine in rat liver kidney was studied vivo. N1-Acetylspermidine metabolized primarily to putrescine while underwent deacetylation yield spermidine. The rate metabolism these two compounds much greater than that exceeded both kidney. These rapid rates could at least part account for the low levels found tissues. differences routes may indicate cellular functions compounds.