Association of Genetic Polymorphisms in Vitamin D Receptor Gene and Susceptibility to Sporadic Prostate Cancer

• DOI: 10.3181/0803-rm-110
• Publication Date: 2008-10-11T01:23:38Z
• Authors: Ilke Hacer Onen; Abdullah Ekmekci; Muzaffer Eroglu; Ece Konac; Suleyman Yesil; Hasan Biri
• Keywords: Genetic predisposition

Genetic and environmental factors are involved in prostate cancer (PCa) etiology. Single nucleotide polymorphisms (SNPs) may contribute to the PCa pathogenesis. The goal of this study is determine role vitamin D receptor (VDR) gene haplotypes development progression sporadic PCa. One hundred thirty-three patients 157 age-matched healthy controls were genotyped for Apa I (rs7975232), Bsm (rs1544410) Taq (rs731236) VDR by using polymerase chain reaction-restriction fragment length polymorphism. An association was observed between polymorphism predisposition (P = 0.03). When compared with AA genotype, there a highly notable difference frequencies Aa 0.02), aa 0.026) ''a'' allele carriers (Aa + aa) 0.009) genotypes. Furthermore, we found statistical control subjects 0.013). genotype distribution similar cases > 0.05). No clinically significant relationship three-locus three within subgroups (defined tumor stage, Gleason score, PSA levels) also analyzed, but no statistically noteworthy As far as know, first which investigates genotypes Turkish population. Our findings suggest that ApaI (rs7975232) play