VariantSalmonellaGenomic Island 1 Antibiotic Resistance Gene Cluster inSalmonella entericaSerovar Albany

• DOI: 10.3201/eid0905.020609
• Publication Date: 2012-06-16T02:54:18Z
• Authors: Benoît Doublet; Renaud Lailler; Danièle Meunier; Anne Brisabois; David Boyd; Michael R. Mulvey; Elisabeth Chaslus...; Axel Cloeckaert
• Keywords: DNA, Bacterial; 0301 basic medicine; integron; Gene Transfer, Horizontal; [SDV]Life Sciences [q-bio]; Molecular Sequence Data; Infectious and parasitic diseases; RC109-216; antibiotique; 03 medical and health sciences; Drug Resistance, Multiple, Bacterial; constin; antibiotic resistance gene cluster; Base Sequence; Research; R; Terminal Repeat Sequences; Genetic Variation; Salmonella enterica; gène de résistance; DT104; Anti-Bacterial Agents; 3. Good health; [SDV] Life Sciences [q-bio]; phénotype; Phenotype; Genes, Bacterial; resrearch; Multigene Family; Medicine; salmonella enterica; Albany; Sequence Alignment

Salmonella genomic island 1 (SGI1) contains an antibiotic resistance gene cluster and has been previously identified in multidrug-resistant Salmonella enterica serovars Typhimurium DT104, Agona, and Paratyphi B. We identified a variant SGI1 antibiotic-resistance gene cluster in a multidrug-resistant strain of S. enterica serovar Albany isolated from food fish from Thailand and imported to France. In this strain, the streptomycin resistance aadA2 gene cassette in one of the SGI1 integrons was replaced by a dfrA1 gene cassette, conferring resistance to trimethoprim and an open reading frame of unknown function. Thus, this serovar Albany strain represents the fourth S. enterica serovar in which SGI1 has been identified and the first SGI1 example where gene cassette replacement took place in one of its integron structures. The antibiotic resistance gene cluster of serovar Albany strain 7205.00 constitutes a new SGI1 variant; we propose a name of SGI1-F.