Human Metapneumovirus RNA in Encephalitis Patient

• DOI: 10.3201/eid1103.040676
• Publication Date: 2012-02-28T15:44:14Z
• Authors: Oliver Schildgen; Thomas Glatzel; Tilman Geikowski; Bärbel Scheibner; Arne Simon; Lutz Bindl; Mark Born; Sergei Viazov; Anja Wilkesmann; Gisela Knöpfle; Michael Roggendorf; Bertfried Matz
• Keywords: Male; human metapneumovirus; Paramyxoviridae Infections; Base Sequence; Molecular Sequence Data; R; Dispatch; Infant; dispatch; Infectious and parasitic diseases; RC109-216; 3. Good health; 03 medical and health sciences; Fatal Outcome; 0302 clinical medicine; fatal encephalitis; Germany; Medicine; Humans; RNA, Viral; Encephalitis, Viral; Metapneumovirus; Sequence Alignment

We describe a fatal case of encephalitis that might be correlated with primary human metapneumovirus (HMPV) encephalitis. Postmortem HMPV RNA was detected in brain and lung tissue samples from the patient. Furthermore, HMPV RNA was found in culture fluids from cells coincubated with lung tissue.