Influenza (H5N1) Viruses in Poultry, Russian Federation, 2005–2006

• DOI: 10.3201/eid1304.061266
• Publication Date: 2009-08-19T21:43:49Z
• Authors: Aleksandr S. Lipatov; Vasily A. Evseenko; Hui-Ling Yen; Anna V. Zaykovskaya; Alexander G. Duri...; Sergey I. Zolotykh; Sergey V. Netesov; Ilya G. Drozdov; Gennadiy G. Onish...; Robert G. Webster; Alexander M. Shes...
• Keywords: Reassortment; Homology; Highly pathogenic

We studied 7 influenza (H5N1) viruses isolated from poultry in western Siberia and the European part of Russian Federation during July 2005-February 2006. Full genome sequences showed high homology to Qinghai-like viruses. Phylogenetic analysis not only a close genetic relationship between H5N1 strains wild migratory waterfowls but also suggested reassortment among analyzed isolates. Analysis deduced amino acid M2 neuraminidase proteins that all isolates are potentially sensitive currently available antiviral drugs. Pathogenicity testing were highly pathogenic chickens; for 3 tested mice 2 ferrets, pathogenicity was heterogeneous. mammalian models generally correlated with Lys at residue 627 polymerase basic protein 2.