Molecular Epidemiology ofCoxiella burnetiifrom Ruminants in Q Fever Outbreak, the Netherlands

• DOI: 10.3201/eid1704.101562
• Publication Date: 2011-04-04T17:34:25Z
• Authors: Hendrik I.J. Roest; Robin C. Ruuls; Jeroen J.H.C. Til...; Marrigje H. Nabuu...; Corné H.W. Klaassen; Piet Vellema; René van den Brom; Daan Dercksen; Willem Wouda; Marcel A.H. Spier...; Arco N. van der Spek; Rob Buijs; Albert G. de Boer; Peter Th.J. Wille...; Fred G. van Zijde...
• Keywords: Coxiella burnetii; Q fever; Zoonosis; Molecular Epidemiology

Abstract Q fever is a zoonosis caused by the bacterium Coxiella burnetii. One of largest reported outbreaks in humans occurred Netherlands starting 2007; epidemiologic investigations identified small ruminants as source. To determine genetic background C. burnetii domestic responsible for human outbreak, we genotyped 126 burnetii–positive samples from using 10-loci multilocus variable-number tandem-repeat analyses panel and compared them with internationally known genotypes. unique genotype predominated dairy goat herds 1 sheep herd outbreak area south Netherlands. On basis 4 loci, this similar to This finding strengthens probability that epidemic