Leptospirosis as Frequent Cause of Acute Febrile Illness in Southern Sri Lanka

• DOI: 10.3201/eid1709.100915
• Publication Date: 2011-09-20T17:21:01Z
• Authors: Megan Reller; Champika Bodinayake; Ajith Nagahawatte; Vasantha Devasiri; Wasantha Kodikara...; John Strouse; Judith Flom; J. Dumler; Christopher Woods
• Keywords: Seroconversion; Seroprevalence; Sri lanka

Abstract To determine the proportion of fevers caused by leptospirosis, we obtained serum specimens and epidemiologic clinical data from patients in Galle, Sri Lanka, March–October 2007. Immunoglobulin M ELISA was performed on paired to diagnose acute (seroconversion or 4-fold titer rise) past (titer without leptospirosis seroprevalence (acute). We compared (individually) diagnostic yield acute-phase impression with for leptospirosis. Of 889 specimens, 120 had leptosoirosis 241 The sensitivity specificity were 17.5% (95% confidence interval [CI] 11.2%–25.5%) 69.2% CI 65.5%–72.7%), respectively, 22.9% 15.4%–32.0%) 91.7% 89.2%–93.8%), respectively. For identifying is insensitive, immunoglobulin results are more insensitive costly. Rapid, pathogen-based tests early diagnosis needed.