Oral Transmission of L-type Bovine Spongiform Encephalopathy in Primate Model

Male 0301 basic medicine 0303 health sciences mouse lemur Prions [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology R Dispatch Brain Infectious and parasitic diseases RC109-216 Animal Feed BSE 3. Good health prion prions and related diseases L-type BSE Encephalopathy, Bovine Spongiform 03 medical and health sciences Medicine Animals Cattle Female bovine spongiform encephalopathy Cheirogaleidae
DOI: 10.3201/eid1801.111092 Publication Date: 2012-01-06T19:55:29Z
ABSTRACT
We report transmission of atypical L-type bovine spongiform encephalopathy to mouse lemurs after oral or intracerebral inoculation with infected bovine brain tissue. After neurologic symptoms appeared, transmissibility of the disease by both inoculation routes was confirmed by detection of disease-associated prion protein in samples of brain tissue.
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