Oral Transmission of L-type Bovine Spongiform Encephalopathy in Primate Model

• DOI: 10.3201/eid1801.111092
• Publication Date: 2012-01-06T19:55:29Z
• Authors: Nadine Mestre-Fra...; Simon Nicot; Sylvie Rouland; Anne-Gaëlle Biacabe; Isabelle Quadrio; Armand Perret-Lia...; Thierry Baron; Jean-Michel Verdier
• Keywords: Bovine spongiform encephalopathy; Transmissibility (structural dynamics)

We report transmission of atypical L-type bovine spongiform encephalopathy to mouse lemurs after oral or intracerebral inoculation with infected brain tissue. After neurologic symptoms appeared, transmissibility the disease by both routes was confirmed detection disease-associated prion protein in samples