Oral Transmission of L-type Bovine Spongiform Encephalopathy in Primate Model

• DOI: 10.3201/eid1801.111092
• Publication Date: 2012-01-06T19:55:29Z
• Authors: Nadine Mestre-Fra...; Simon Nicot; Sylvie Rouland; Anne-Gaëlle Biacabe; Isabelle Quadrio; Armand Perret-Lia...; Thierry Baron; Jean-Michel Verdier
• Keywords: Male; 0301 basic medicine; 0303 health sciences; mouse lemur; Prions; [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology; R; Dispatch; Brain; Infectious and parasitic diseases; RC109-216; Animal Feed; BSE; 3. Good health; prion; prions and related diseases; L-type BSE; Encephalopathy, Bovine Spongiform; 03 medical and health sciences; Medicine; Animals; Cattle; Female; bovine spongiform encephalopathy; Cheirogaleidae

We report transmission of atypical L-type bovine spongiform encephalopathy to mouse lemurs after oral or intracerebral inoculation with infected bovine brain tissue. After neurologic symptoms appeared, transmissibility of the disease by both inoculation routes was confirmed by detection of disease-associated prion protein in samples of brain tissue.