Eastern Equine Encephalitis in Children, Massachusetts and New Hampshire,USA, 1970–2010

• DOI: 10.3201/eid1902.120039
• Publication Date: 2013-01-09T01:26:27Z
• Authors: Michael A. Silverman; John Misasi; Sandra Smole; Henry A. Feldman; Adam B. Cohen; Sandro Santagata; Michael McManus; Asim A. Ahmed
• Keywords: Male; Adolescent; Fever; Prodromal Symptoms; Infectious and parasitic diseases; RC109-216; 03 medical and health sciences; Seizures; Humans; New Hampshire; Child; 0303 health sciences; Eastern equine encephalitis; R; Headache; Brain; Infant; Eastern equine encephalitis virus; Encephalomyelitis, Eastern Equine; Length of Stay; 3. Good health; Radiography; arbovirus; pediatric; Treatment Outcome; Massachusetts; Child, Preschool; Synopsis; Encephalitis; Medicine; Female

We describe the clinical, laboratory, and radiographic characteristics of 15 cases of eastern equine encephalitis in children during 1970-2010. The most common clinical and laboratory features were fever, headache, seizures, peripheral leukocytosis, and cerebrospinal fluid neutrophilic pleocytosis. Radiographic lesions were found in the basal ganglia, thalami, and cerebral cortex. Clinical outcomes included severe neurologic deficits in 5 (33%) patients, death of 4 (27%), full recovery of 4 (27%), and mild neurologic deficits in 2 (13%). We identify an association between a short prodrome and an increased risk for death or for severe disease.