Human Granulocytic Anaplasmosis, Japan

• DOI: 10.3201/eid1902.120855
• Publication Date: 2013-01-08T22:56:08Z
• Authors: Norio Ohashi; Gaowa; Fumihiko Wuritu; Dongxing Kawamori; Yuko Wu; Seizou Yoshikawa; Kazutoshi Chiya; Toyohiko Fukunaga; Masaaki Funato; Shiojiri; Hideki Nakajima; Yoshiji Hamauzu; Ai Takano; Hiroki Kawabata; Shuji Ando; Toshio Kishimoto
• Keywords: Anaplasma phagocytophilum; Anaplasmosis; Anaplasmataceae; Tick-borne disease; Orientia tsutsugamushi; Ehrlichiosis

Abstract We retrospectively confirmed 2 cases of human Anaplasma phagocytophilum infection. Patient blood samples contained unique p44/msp2 for the pathogen, and antibodies bound to A. antigens propagated in THP-1 rather than HL60 cells. Unless both cell lines are used serodiagnosis rickettsiosis-like infections, granulocytic anaplasmosis could go undetected.