Streptococcus mitisStrains Causing Severe Clinical Disease in Cancer Patients
0301 basic medicine
Bacteremia
Streptococcus mitis
Infectious and parasitic diseases
RC109-216
Severity of Illness Index
Cohort Studies
Mice
03 medical and health sciences
Neoplasms
Streptococcal Infections
neutropenia
Animals
Humans
bacteremia
Phylogeny
0303 health sciences
Genes, Essential
Virulence
Research
R
viridans group streptococci
3. Good health
Pitt bacteremia score
Disease Models, Animal
Genes, Bacterial
13. Climate action
Medicine
Female
cancer patients
Genome, Bacterial
Multilocus Sequence Typing
DOI:
10.3201/eid2005.130953
Publication Date:
2014-03-26T18:03:55Z
AUTHORS (8)
ABSTRACT
The genetically diverse viridans group streptococci (VGS) are increasingly recognized as the cause of a variety of human diseases. We used a recently developed multilocus sequence analysis scheme to define the species of 118 unique VGS strains causing bacteremia in patients with cancer; Streptococcus mitis (68 patients) and S. oralis (22 patients) were the most frequently identified strains. Compared with patients infected with non-S. mitis strains, patients infected with S. mitis strains were more likely to have moderate or severe clinical disease (e.g., VGS shock syndrome). Combined with the sequence data, whole-genome analyses showed that S. mitis strains may more precisely be considered as >2 species. Furthermore, we found that multiple S. mitis strains induced disease in neutropenic mice in a dose-dependent fashion. Our data define the prominent clinical effect of the group of organisms currently classified as S. mitis and lay the groundwork for increased understanding of this understudied pathogen.
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CITATIONS (122)
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